Morphological characterization of postembryonic development of blood–spleen barrier in duck
| Autor: | Imran Tarique, Sheng Yang, Xuejing Sun, Mengdi Xu, Qiusheng Chen, Ping Yang, Wenqian Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
White pulp
high endothelial cell Reticular fiber Pathology medicine.medical_specialty duck Spleen blood–spleen barrier Biology law.invention 03 medical and health sciences law medicine Animals 030304 developmental biology lcsh:SF1-1100 Basement membrane 0303 health sciences reticular fiber Immunity 0402 animal and dairy science Endothelial Cells 04 agricultural and veterinary sciences General Medicine Immunology Health and Disease 040201 dairy & animal science Ducks medicine.anatomical_structure Lymphatic system Reticular connective tissue Red pulp Animal Science and Zoology lcsh:Animal culture Electron microscope |
| Zdroj: | Poultry Science, Vol 99, Iss 8, Pp 3823-3830 (2020) Poultry Science |
| ISSN: | 0032-5791 |
| Popis: | The spleen is the largest peripheral lymphoid organ and an important site of immune response, in which the blood–spleen barrier (BSB) plays a significant role to resist various pathogens. The BSB structure of duck spleen is different from that of chicken and mammals. However, no information about the development of BSB after the postembryonic age has been reported in ducks. The current study observed the spleen of 1, 7, 14, 21, 35, and 60-day-old ducks by light and electron microscopy to analyze the cellular structural development. The results showed that the spleen index was continuously increased from 1 to 14-day-old ducks. During their early age, the spleen of ducks showed no definite zone of white and red pulp, but the area of the white pulp was large compared to that of the red pulp. The diameter of the ellipsoid was constantly increased in up to 35-day-old duck spleen, while the periellipsoidal lymphatic sheath (PELS) and periarterial lymphatic sheath continuously developed after 1 D. The reticular fibers developed with age; their branching reached the ellipsoidal wall to show a developed framework in the BSB of 14-day-old ducks. After 7 D, the endothelial cells of the sheathed capillary showed a typical cuboidal shape; between these cells, the gaps increased as age advanced, while the thickness of the basement membrane and collagen fibers increased in 35-day-old ducks. The mechanical filtration function of BSB by intravenous injection showed a 1-layer ring of carbon particles restricted in the white pulp in 1-day-old duck spleen; however, in 14 to 60 D, these particles were restricted in the ellipsoid and PELS, forming 2-layer rings of carbon particles. Collectively, the cellular features of the duck BSB developed up to 35 D of postembryonic age to perform their immune function. |
| Databáze: | OpenAIRE |
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