Pregnancy modulates the allergen-induced cytokine production differently in allergic and non-allergic women
| Autor: | Camilla Janefjord, Göran Berg, Leif Matthiesen, Martina Sandberg Abelius, Jan Ernerudh, Maria C. Jenmalm, Malin Jedenfalk |
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| Rok vydání: | 2017 |
| Předmět: |
Hypersensitivity
Immediate 0301 basic medicine Chemokine Allergy Respiratory Medicine and Allergy medicine.medical_treatment Immunology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Allergen Pregnancy medicine Humans Immunology and Allergy CXCL10 CCL17 Lungmedicin och allergi biology Tetanus business.industry Allergens medicine.disease Pregnancy Complications 030104 developmental biology Cytokine 030228 respiratory system Case-Control Studies Pediatrics Perinatology and Child Health biology.protein allergy birch cat chemokines cytokines immune regulation pregnancy rhinitis T cells Cytokines Female Chemokines business Biomarkers Follow-Up Studies |
| Zdroj: | Pediatric Allergy and Immunology. 28:818-824 |
| ISSN: | 0905-6157 |
| Popis: | Background: The immunological environment during pregnancy may differ between allergic and non-allergic women. This study investigates the effect of maternal allergy on the allergen-induced cytokine and chemokine levels and whether pregnancy modulates these immune responses differently in allergic and non-allergic women. Methods: The birch-, cat-, phytohemagglutinin- and tetanus toxoid-induced interferon-gamma(IFN-gamma), interleukin (IL)-4, IL-5, IL-10, IL-13, the T-helper 1 (Th1)-associated chemokine CXCL10 and the Th2-associated chemokine CCL17 levels were quantified in 20 women with allergic symptoms (sensitized, n=13) and 36 women without allergic symptoms (non-sensitized, n=30) at gestational weeks 10-12, 15-16, 25, 35 and 2 and 12months post-partum. Results: Birch-, but not cat-induced, IL-5, IL-13 and CCL17 levels were increased during pregnancy as compared to post-partum in the sensitized women with allergic symptoms. In contrast, cat-, but not birch-induced, IL-5 and IL-13 levels were increased during pregnancy as compared to post-partum in the non-sensitized women without allergic symptoms. Furthermore, IFN-gamma secretion was increased in the first and decreased in the second and third trimesters in response to birch and decreased in the third trimester in response to cat as compared to post-partum in the non-sensitized women without allergic symptoms. Increased allergen-induced IL-4, IL-5 and IL-13 levels were associated with allergic symptoms and sensitization. Conclusions: Pregnancy had a clear effect on the allergen-induced IL-5, IL-13, CCL17, IFN-gamma and CXCL10 production, with distinct enhanced Th2-responses to birch in the allergic group and to cat in the non-allergic group. Funding Agencies|Swedish Research Council [73X-15335-01A, 74X-20146-01-2]; National Swedish Association against Allergic Diseases; National Heart and Lung Association; Vardal Foundation for Health Care Sciences and Allergy Research; Olle Engkvist Foundation; Cancer and Allergy Association; Samariten Foundation; Queen Silvia research foundation; Ellen, Walter and Lennart Hesselmans foundation; County Council of Ostergotland |
| Databáze: | OpenAIRE |
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