Six-week follow-up after HIV-1 exposure: a position statement from the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy
| Autor: | Gordana Bogdanovic, Karin Tegmark Wisell, Per Follin, Per Hagstam, Martina Sundqvist, Christina Carlander, Helena Ström, Leo Flamholc, Veronica Svedhem Johansson, Jan Albert, Lars Navér, Hans Gaines, Maria Axelsson, Torsten Berglund, Anders Tegnell, Magnus Gisslén, Anders Blaxhult, Anders Sönnerborg, Rigmor Thorstensson, Jenny Persson Blom, Axana Haggar, Maria Brytting, Agneta Samuelson, Marcus Johansson |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Time Factors Anti-HIV Agents HIV Antigens medicine.medical_treatment Health Personnel 030106 microbiology Human immunodeficiency virus (HIV) HIV Infections HIV Antibodies medicine.disease_cause Chemoprevention Serology 03 medical and health sciences 0302 clinical medicine Occupational Exposure Agency (sociology) medicine Humans Serologic Tests 030212 general & internal medicine Post-exposure prophylaxis Reference group Sweden General Immunology and Microbiology business.industry Public health General Medicine Infectious Diseases Early Diagnosis Family medicine Chemoprophylaxis Immunology HIV-2 HIV-1 business Post-Exposure Prophylaxis |
| Zdroj: | Infectious diseases (London, England). 48(2) |
| ISSN: | 2374-4243 |
| Popis: | In 2014 the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy (RAV) conducted a review and analysis of the state of knowledge on the duration of follow-up after exposure to human immunodeficiency virus (HIV). Up until then a follow-up of 12 weeks after exposure had been recommended, but improved tests and new information on early diagnosis motivated a re-evaluation of the national recommendations by experts representing infectious diseases and microbiology, county medical officers, the RAV, the Public Health Agency, and other national authorities. Based on the current state of knowledge the Public Health Agency of Sweden and the RAV recommend, starting in April 2015, a follow-up period of 6 weeks after possible HIV-1 exposure, if HIV testing is performed using laboratory-based combination tests detecting both HIV antibody and antigen. If point-of-care rapid HIV tests are used, a follow-up period of 8 weeks is recommended, because currently available rapid tests have insufficient sensitivity for detection of HIV-1 antigen. A follow-up period of 12 weeks is recommended after a possible exposure for HIV-2, since presently used assays do not include HIV-2 antigens and only limited information is available on the development of HIV antibodies during early HIV-2 infection. If pre- or post-exposure prophylaxis is administered, the follow-up period is recommended to begin after completion of prophylaxis. Even if infection cannot be reliably excluded before the end of the recommended follow-up period, HIV testing should be performed at first contact for persons who seek such testing. |
| Databáze: | OpenAIRE |
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