An Exploratory Examination of Neonatal Cytokines and Chemokines as Predictors of Autism Risk: The Early Markers for Autism Study
| Autor: | Karen L. Jones, Lisa A. Croen, Judith A Van de Water, Luke Heuer, Paul Ashwood, Robert H. Yolken, Martin Kharrazi, Gerald N. DeLorenze, Cathleen K. Yoshida, Ousseny Zerbo, Robin L Hansen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Male Developmental delay Autism Spectrum Disorder Developmental Disabilities Autism Reproductive health and childbirth Logistic regression Medical and Health Sciences California 0302 clinical medicine Risk Factors Neonatal Medicine Pediatric Psychiatry education.field_of_study screening and diagnosis Biological Sciences Detection Mental Health Autism spectrum disorder Chemokine Biomarker (medicine) Cytokines Female Chemokines 4.2 Evaluation of markers and technologies medicine.medical_specialty Intellectual and Developmental Disabilities (IDD) Population Article 03 medical and health sciences Immune system Clinical Research Internal medicine mental disorders Humans Autistic Disorder education Cytokine Biological Psychiatry business.industry Prevention Inflammatory and immune system Psychology and Cognitive Sciences Infant Newborn Infant Odds ratio Perinatal Period - Conditions Originating in Perinatal Period medicine.disease Newborn Confidence interval Brain Disorders 030104 developmental biology Early Diagnosis Logistic Models Case-Control Studies Bloodspot business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Biol Psychiatry Biological psychiatry, vol 86, iss 4 |
| Popis: | Background The identification of an early biomarker for autism spectrum disorder (ASD) would improve the determination of risk, leading to earlier diagnosis and, potentially, earlier intervention and improved outcomes. Methods Data were generated from the Early Markers for Autism study, a population-based case-control study of prenatal and neonatal biomarkers of ASD. Newborn bloodspots of children with ASD (n = 370), children with developmental delay (n = 140), and general population (GP) controls (n = 378) were analyzed for 42 different immune markers using a Luminex multiplex platform. Comparisons of immune marker concentrations between groups were examined using logistic regression and partial least squares discriminant analysis. Results Children with ASD had significantly increased neonatal levels of interleukin-6 (IL-6) and IL-8 compared with GP controls. An increase in IL-8 was especially significant in the ASD group with early onset compared with the GP group, with an adjusted odds ratio of 1.97 (95% confidence interval, 1.39–2.83; p = .00014). In addition, children with ASD had significantly elevated levels of eotaxin-1, interferon-γ, and IL-12p70 relative to children with developmental delay. We observed no significant differences in levels of immune markers between the developmental delay and GP groups. Conclusions Elevated levels of some inflammatory markers in newborn bloodspots indicated a higher degree of immune activation at birth in children who were subsequently diagnosed with ASD. The data from this exploratory study suggest that with further expansion, the development of neonatal bloodspot testing for cytokine/chemokine levels might lead to the identification of biomarkers that provide an accurate assessment of ASD risk at birth. |
| Databáze: | OpenAIRE |
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