CpG islands under selective pressure are enriched with H3K4me3, H3K27ac and H3K36me3 histone modifications
| Autor: | Most Mauluda Akhtar, Giovanni Scala, Antonella Monticelli, Sergio Cocozza, Gennaro Miele |
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| Přispěvatelé: | Akhtar, Mm, Scala, Giovanni, Cocozza, Sergio, Miele, Gennaro, Monticelli, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Histone H3 Lysine 4
Biology Methylation Cell Line Epigenesis Genetic Evolution Molecular Histones Histone H3 CpG islands Histone H1 Histone methylation Histone H2A Histone code Humans histone modification Selection Genetic Promoter Regions Genetic Ecology Evolution Behavior and Systematics Epigenomics Genetics Lysine H3K36me3 Computational Biology Epigenetic Acetylation H3K4me3 H3K27ac Chromatin Selective pressure Histone methyltransferase Research Article |
| Zdroj: | BMC evolutionary biology (Online) 13 (2013). doi:10.1186/1471-2148-13-145 info:cnr-pdr/source/autori:Akhtar MM, Scala G, Cocozza S, Miele G, Monticelli A./titolo:CpG islands under selective pressure are enriched with H3K4me3, H3K27ac and H3K36me3 histone modifications./doi:10.1186%2F1471-2148-13-145/rivista:BMC evolutionary biology (Online)/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume:13 BMC Evolutionary Biology |
| DOI: | 10.1186/1471-2148-13-145 |
| Popis: | Background Histone modification is an epigenetic mechanism that influences gene regulation in eukaryotes. In particular, histone modifications in CpG islands (CGIs) are associated with different chromatin states and with transcription activity. Changes in gene expression play a crucial role in adaptation and evolution. Results In this paper, we have studied, using a computational biology approach, the relationship between histone modifications in CGIs and selective pressure in Homo sapiens. We considered three histone modifications: histone H3 lysine 4 trimethylation (H3K4me3), histone H3 lysine 27 acetylation (H3K27ac) and histone H3 lysine 36 trimethylation (H3K36me3), and we used the publicly available genomic-scale histone modification data of thirteen human cell lines. To define regions under selective pressure, we used three distinct signatures that mark selective events from different evolutionary periods. We found that CGIs under selective pressure showed significant enrichments for histone modifications. Conclusion Our result suggests that, CGIs that have undergone selective events are characterized by epigenetic signatures, in particular, histone modifications that are distinct from CGIs with no evidence of selection. |
| Databáze: | OpenAIRE |
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