Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance
| Autor: | N M Wilson, I Narang, Andrew Bush, R Ersu |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pathology Adolescent Cystic Fibrosis Nose Nitric Oxide Cystic fibrosis Gastroenterology Nitric oxide chemistry.chemical_compound Forced Expiratory Volume Internal medicine otorhinolaryngologic diseases medicine Humans Respiratory system Child Asthma Primary ciliary dyskinesia Bronchiectasis Lung Kartagener Syndrome business.industry Respiratory disease respiratory system medicine.disease medicine.anatomical_structure Breath Tests ROC Curve chemistry Original Article business Biomarkers |
| Zdroj: | Thorax. 57:586-589 |
| ISSN: | 0040-6376 |
| DOI: | 10.1136/thorax.57.7.586 |
| Popis: | Background: The levels of exhaled and nasal nitric oxide (eNO and nNO) in groups of patients with inflammatory lung diseases are well documented but the diagnostic use of these measurements in an individual is unknown. Methods: The levels of nNO and eNO were compared in 31 children with primary ciliary dyskinesia (PCD), 21 with non-CF bronchiectasis (Bx), 17 with cystic fibrosis (CF), 35 with asthma (A), and 53 healthy controls (C) using a chemiluminescence NO analyser. A diagnostic receiver-operator characteristic (ROC) curve for PCD using NO was constructed. Results: The median (range) levels of nNO in parts per billion (ppb) in PCD, Bx, CF, and C were 60.3 (3.3–920), 533.6 (80–2053), 491.3 (31–1140), and 716 (398–1437), respectively; nNO levels were significantly lower in PCD than in all other groups (p |
| Databáze: | OpenAIRE |
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