Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA)
| Autor: | Mireille Van Goethem, Federica Pediconi, Catherine Depretto, Corinne Balleyguier, Francesco Cartia, Stefania Montemezzi, Rubina M. Trimboli, Ritse M. Mann, Giovanni Di Leo, Inge Marie Obdeijn, Marc B. I. Lobbes, Umit Aksoy Ozcan, Fiona J. Gilbert, Paola Clauser, Raffaele Ienzi, Heike Preibsch, Massimo Calabrese, Ozden S. Ulus, José Luis Raya Povedano, Andrea Cozzi, Danubia A. de Andrade, Sarah Hilborne, Katja Pinker, Julia Camps Herrero, Jeroen Veltman, Steven E. Harms, Marcos F. de Lima Docema, Chiara Zuiani, Evelyn Wenkel, Peter Bult, Stefanie Weigel, Enrico Cassano, Gianfranco Scaperrotta, Donna Taylor, Margrethe S. Schlooz, Massimo Bazzocchi, Claudio Losio, Rossano Girometti, Thomas H. Helbich, Gabor Forrai, Simone Schiaffino, Daniela Sacchetto, Botond K. Szabó, Marina Benito, Nehmat Houssami, Valeria Dominelli, Francesco Sardanelli |
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| Přispěvatelé: | Acibadem University Dspace, Sardanelli, Francesco [0000-0001-6545-9427], Apollo - University of Cambridge Repository, Radiology & Nuclear Medicine, Gilbert, Fiona [0000-0002-0124-9962], Beeldvorming, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: DA BV Medisch Specialisten Radiologie (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
breast cancer
breast-conserving surgery magnetic resonance imaging mastectomy reoperation adolescent adult aged aged 80 and over breast female humans segmental middle aged preoperative care young adult breast neoplasms medicine.medical_treatment Mastectomy Segmental RECOMMENDATIONS Breast cancer 80 and over Breast-conserving surgery Breast MRI Breast Neoadjuvant therapy Mastectomy Neuroradiology Aged 80 and over OUTCOMES Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17] medicine.diagnostic_test General Medicine Middle Aged Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] SURGICAL-MANAGEMENT Magnetic resonance imaging Reoperation Female CONSERVATION THERAPY Radiology Adult medicine.medical_specialty Adolescent Breast Neoplasms Young Adult SDG 3 - Good Health and Well-being Preoperative Care medicine Humans Mammography Radiology Nuclear Medicine and imaging METAANALYSIS Aged Computer. Automation business.industry medicine.disease Surgery Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] Human medicine business PREOPERATIVE MRI |
| Zdroj: | European Radiology European Radiology, 32, 1611-1623 European Radiology, 32(3), 1611-1623. Springer-Verlag European radiology European Radiology, 32, 3, pp. 1611-1623 European Radiology, 32(3), 1611-1623. Springer, Cham |
| ISSN: | 0938-7994 |
| Popis: | Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p p p p Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making. |
| Databáze: | OpenAIRE |
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