Organising cells into tissues: new roles for cell adhesion molecules in planar cell polarity
Autor: | Sakura Saburi, Helen McNeill |
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Rok vydání: | 2005 |
Předmět: |
chemistry.chemical_classification
Frizzled animal structures Cell adhesion molecule Cadherin Wnt signaling pathway Cell Polarity Gene Expression Regulation Developmental Small G Protein Cell Biology Biology Models Biological Hedgehog signaling pathway Epithelium respiratory tract diseases Dishevelled Cell biology medicine.anatomical_structure chemistry medicine Animals Drosophila Proteins Drosophila Cell Adhesion Molecules Signal Transduction |
Zdroj: | Current Opinion in Cell Biology. 17:482-488 |
ISSN: | 0955-0674 |
DOI: | 10.1016/j.ceb.2005.08.011 |
Popis: | Planar cell polarity (PCP) is the coordinated organization of cells within the plane of the epithelium, first described in Drosophila. A Frizzled signalling pathway dedicated to PCP (the non-canonical Frizzled pathway) acts through Dishevelled and small G proteins, as does the classical Wnt pathway, but then diverges downstream of Dishevelled. Recent studies have demonstrated a crucial role for several atypical cadherin molecules (Fat, Dachsous and Flamingo) in controlling PCP signalling. Recent work has also indicated that the first sign of PCP during development is the polarized localization of PCP proteins (Frizzled, Flamingo, Dishevelled, etc). Exciting new data reveal that this PCP pathway is conserved to man. |
Databáze: | OpenAIRE |
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