Effects of Taltrimide, an Experimental Taurine Derivative, on Photoconvulsive Response in Epileptic Patients
| Autor: | Paavo Riekkinen, Keijo Koivisto, Tapani Keränen, Pertti J. Neuvonen, O. Tokola, V. S. J. Partanen |
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| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Taurine Indoles Photic Stimulation medicine.medical_treatment Phthalimides Electroencephalography 03 medical and health sciences chemistry.chemical_compound Epilepsy 0302 clinical medicine Oral administration Hyperventilation medicine Animals Humans Intermittent photic stimulation 030304 developmental biology 0303 health sciences medicine.diagnostic_test business.industry Brain medicine.disease 3. Good health Surgery Anticonvulsant Neurology chemistry Anesthesia Anticonvulsants sense organs Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Epilepsia. 28:133-137 |
| ISSN: | 1528-1167 0013-9580 |
| DOI: | 10.1111/j.1528-1157.1987.tb03638.x |
| Popis: | Taltrimide is a lipophilic taurine derivative with definitive anticonvulsive effects in experimental epilepsy models. In this study, taltrimide was administered for 6 days, and the effects of the treatment on photoconvulsive response in EEG in eight epileptic patients were evaluated. Discharges provoked by intermittent photic stimulation (IPS) were increased by greater than 50% in four patients after taltrimide treatment. Only one patient had reduction of sensitivity. There was only a slight change in discharges after hyperventilation and no change in spontaneous paroxysms. The effects of taltrimide on photosensitivity appear to be rather specific. The study does not reveal anticonvulsive effects of taltrimide in humans. |
| Databáze: | OpenAIRE |
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