Synthesis and antimicrobial activity of some 2-[1-(4-oxo-3,4-dihydrophthalazine-1-yl)alkyl]-1H-isoindole-1,3(2H)-dione and their imidoxy derivatives
| Autor: | Jawahar L. Jat, Vijay K. Salvi, Ganpat L. Talesara, Dinesh Bhambi |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | ARKIVOC, Vol 2006, Iss 14, Pp 133-140 (2007) |
| ISSN: | 1551-7012 1551-7004 |
| Popis: | In this study, a series of 2-[(4-substituted phthalazine-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones 6a-d and 2-{2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindole-2-yl-alkyl)1-oxo phthalazine-2(1H)yl]alkoxy}-1H-isoindole-1,3(2H)-diones 7a-d have been synthesized from phthalyl derivatives of amino acids 1a-b as starting material. The structures of these compounds were confirmed by IR, H NMR and Mass spectral studies. Synthesized compounds 6a-d and 7a-d showed significant antimicrobial activity. |
| Databáze: | OpenAIRE |
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