Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine
| Autor: | J.C. Fowler, Brett Froeliger, Steven T. Szabo, Tong H. Lee |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Nicotine Nicotinic Antagonists Mecamylamine Motor Activity Pharmacology Article Rats Sprague-Dawley Behavioral Neuroscience Cocaine Dopamine Uptake Inhibitors medicine Animals Nicotinic Agonists Nicotinic Antagonist Sensitization Kindling Antagonist Rats Substance Withdrawal Syndrome Nicotinic acetylcholine receptor medicine.anatomical_structure Nicotinic agonist Psychology medicine.drug |
| Zdroj: | Behavioural Brain Research. 262:42-46 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2013.12.051 |
| Popis: | Cocaine abuse is associated with a high prevalence of nicotine dependence. In animals, nicotinic antagonists have been reported to block the development of cocaine behavioral sensitization and to attenuate cocaine place preference or self-administration. In the present study, we have determined: (1) changes in the locomotor responses to nicotine challenge during the first week of withdrawal from daily cocaine pretreatment; and (2) effects of the non-selective nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine given during the first 5 days of cocaine withdrawal on the maintenance of cocaine behavioral sensitization. Male Sprague-Dawley rats were pretreated with daily saline (SI) or cocaine (CI) injections for 14 days. In Experiment 1, separate animals in the SI and CI groups received a single nicotine challenge on day 1, 3, or 7 of withdrawal from their respective pretreatments. The CI group displayed enhanced locomotor responses to nicotine as compared to SI controls on days 3 and 7 of withdrawal, but not day 1. In Experiment 2, SI and CI animals were treated once a day with either saline or mecamylamine during the first 5 days of withdrawal, and were subsequently challenged with single cocaine injections on both withdrawal days 7 and 14. Mecamylamine treatment significantly attenuated expression of cocaine behavioral sensitization on both withdrawal days 7 and 14. Time-dependent changes in nicotinic responses occur during the first week of cocaine withdrawal, and intact nAChR neurotransmission during this period may be necessary for maintenance of cocaine behavioral sensitization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect