Dichotomous Locomotor Recoveries Are Predicted by Acute Changes in Segmental Blood Flow after Thoracic Spinal Contusion Injuries in Pigs
| Autor: | Yohjan Nunez-Gomez, Andrea J. Santamaria, Juan P. Solano, James D. Guest, Kyle R. Padgett, Luis Guada, Francisco D. Benavides |
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| Rok vydání: | 2018 |
| Předmět: |
030506 rehabilitation
Swine Hindlimb medicine.disease_cause Weight-bearing 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid medicine Animals Spinal cord injury Spinal Cord Injuries medicine.diagnostic_test business.industry Ultrasound Magnetic resonance imaging Ultrasonography Doppler Blood flow Recovery of Function Spinal cord medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Spinal Cord Anesthesia Cerebrovascular Circulation Swine Miniature Female Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery Locomotion |
| Zdroj: | Journal of neurotrauma. 36(9) |
| ISSN: | 1557-9042 |
| Popis: | Neuroimaging facilitates the translation of animal pre-clinical research to human application. The large porcine spinal cord is useful for testing invasive interventions. Ideally, the safety and efficacy of a delayed intervention is tested in pigs that have recovered sufficiently after spinal cord injury (SCI) to allow either deterioration or improvement of function to be detected. We set out to create moderate severity T9 injuries in Yucatan minipigs by conducting a bridging study adapting methods previously developed in infant piglets. The injury severity was varied according to two pneumatic impactor parameters: the piston compression depth into tissue or the velocity. To stratify locomotor recovery, a 10-point scale used in prior piglet studies was redefined through longitudinal observations of spontaneous recovery. Using hindlimb body weight support to discriminate injury severity, we found that end-point recovery was strongly bimodal to either non-weight-bearing plegia with reciprocating leg movements ( |
| Databáze: | OpenAIRE |
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