Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions
| Autor: | Etienne Testa, Gersende Alphonse, Claire Rodriguez-Lafrasse, Caterina Monini, Michael Beuve |
|---|---|
| Přispěvatelé: | Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Service de biochimie, hospices civils de Lyon |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Short Communication lcsh:R895-920 medicine.medical_treatment Monoenergetic ions Linear energy transfer Benchmark lcsh:RC254-282 030218 nuclear medicine & medical imaging Ion 03 medical and health sciences 0302 clinical medicine Hadrontherapy medicine Relative biological effectiveness Radiology Nuclear Medicine and imaging Irradiation Physics Radiation Particle therapy Kinetic model Estimator Experimental data lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation Computational physics 030220 oncology & carcinogenesis [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] Biophysical modeling |
| Zdroj: | Physics and Imaging in Radiation Oncology, Vol 12, Iss, Pp 17-21 (2019) Physics and Imaging in Radiation Oncology Physics and Imaging in Radiation Oncology, 2019, 12, pp.17-21. ⟨10.1016/j.phro.2019.10.004⟩ |
| ISSN: | 2405-6316 |
| Popis: | Highlights • The accuracy of biophysical modeling is crucial for particle therapy. • Comparison of LEM(I-IV), MKM and NanOx models with data for 3 cell lines. • χ2 scoring for α(LET) curves. • NanOx yields the highest score more often than the other models. The relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV), the Microdosimetric Kinetic Model (MKM) and the NanOx model for HSG, V79 and CHO-K1 cells in response to monoenergetic irradiations. Although the LEM IV and the MKM predictions accurately reproduced the trend observed in the data, NanOx yielded a better agreement than the other models for more irradiation configurations. Its χ2 estimator was indeed the lowest for three over seven considered cases. |
| Databáze: | OpenAIRE |
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