Relationship between lung tissue and blood plasma concentrations of inhaled budesonide
| Autor: | C. J. J. Westermann, O. Selroos, S. Edsbácker, J. L. T. M. Aumann, M. Tönnesson, J. M. M. Van Den Bosch |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Budesonide Drug Pathology medicine.medical_specialty medicine.drug_class media_common.quotation_subject Pharmaceutical Science Pharmacology Pharmacokinetics Pregnenediones Administration Inhalation Blood plasma medicine Humans Tissue Distribution Pharmacology (medical) Glucocorticoids Lung Aged media_common Aerosols Inhalation business.industry Respiratory disease General Medicine Middle Aged respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure Corticosteroid Female business medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 14:455-459 |
| ISSN: | 1099-081X 0142-2782 |
| DOI: | 10.1002/bdd.2510140511 |
| Popis: | In 11 patients, in whom a lung lobe or whole lung was to be resected, a single dose of 1.6 mg inhaled budesonide was given pre-operatively. In 9 of them, concentrations of the drug in both lung tissue and blood plasma were measured. Budesonide concentrations in lung tissue, at least 90 min after dosage, were 2.1-8.9 nmol kg-1. Concentrations in blood plasma (0.27-1.1 nmol kg-1) were 1/8th of those in lung tissue. |
| Databáze: | OpenAIRE |
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