Mannose-conjugated curcumin-chitosan nanoparticles: Efficacy and toxicity assessments against Leishmania donovani
| Autor: | Shyam Sundar, Ravi R. Patel, Marvis Monteiro, Shyam Lal Mudavath, Pramila Chaubey, Vasanti Suvarna, Sundeep Chaurasia, Brahmeshwar Mishra |
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| Rok vydání: | 2017 |
| Předmět: |
Curcumin
Leishmania donovani Mannose 02 engineering and technology Pharmacology 010402 general chemistry 01 natural sciences Biochemistry Cell Line Chitosan chemistry.chemical_compound Structural Biology In vivo Humans Cytotoxicity Molecular Biology Drug Carriers biology Macrophages General Medicine 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences chemistry Cell culture Leishmaniasis Visceral Nanoparticles 0210 nano-technology Intracellular |
| Zdroj: | International journal of biological macromolecules. 111 |
| ISSN: | 1879-0003 |
| Popis: | Aim was to fabricate and optimize CUR-loaded mannose-functionalized chitosan nanoparticles (Cur-MCN) which overcome the limitations of drugs to reach the intracellular locations and to establish its therapeutic potential in visceral leishmaniasis by targeting of CUR to macrophages. Cur-MCN were developed by mannose-conjugated chitosan and have been tested for their efficacy and toxicit. In vivo antileishmanial activity in hamsters has shown significantly greater suppression of parasite replication in the spleen with Cur-MCN than unconjugated chitosan nanoparticles. The in vitro cytotoxicity study against the J774A.1 cell line demonstrated its comparative non-toxicity towards the macrophage cells. The potential of Cur-MCN was also confirmed by minimal observed cytotoxicity in our in vivo studies. |
| Databáze: | OpenAIRE |
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