Evaluation of recurrent disease in the re-staging of colorectal cancer by 18F-FDG PET/CT: Use of CEA and CA 19–9 in patient selection
| Autor: | Alessandro Fiorentini, Erika Palombo, Carmen Di Russo, Annamaria Lacanfora, Daniele Di Biagio, Orazio Schillaci, Roberta Danieli, Agostino Chiaravalloti, Ettore Squillaci, Davide Rinino |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Colorectal cancer 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Carcinoembryonic antigen Settore MED/36 - Diagnostica per Immagini e Radioterapia Internal medicine medicine neoplasms Fluorodeoxyglucose medicine.diagnostic_test Receiver operating characteristic biology business.industry Cancer medicine.disease Confidence interval 3. Good health Positron emission tomography 030220 oncology & carcinogenesis biology.protein CA19-9 business Nuclear medicine medicine.drug |
| Zdroj: | Oncology Letters. 12:4209-4213 |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | The aim of the present retrospective study was to evaluate the sensitivity and specificity of fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing the recurrence of colorectal cancer (CRC) with regard to carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9). 18F-FDG PET/CT was performed in 100 patients for the re-staging of CRC. Therapy was discontinued prior to the examination. The mean (± standard deviation) CEA value (measured ~30 days prior to PET/CT examination) was 23.71 (±107) ng/ml, whereas the CA 19-9 value was 72 (±190.3) U/ml. Differences in CEA and CA 19-9 values in patients with scans that were positive or negative for recurrence were analyzed by means of a receiver operating characteristic (ROC) curve. ROC curves were used for the calculation of the sensitivity and specificity of 18F-FDG PET/CT for the CEA and CA 19-9 levels. The results of the 18F-FDG PET/CT were found to be associated with the CEA level (P=0.001), but not with the CA 19-9 level (P=0.43). PET/CT was positive for recurrence in 60 patients (60.0%), whose mean CEA and CA 19-9 values were 33.07±136.7 ng/ml and 75.24±192.3 U/ml, respectively. PET/CT was negative for recurrence in 40 patients (40.0%), whose mean CEA and CA 19-9 values were 10.15±30 ng/ml and 67.76±190 U/ml, respectively. On the basis of ROC curve analysis, the best compromise between sensitivity and specificity was achieved for CEA levels of 3.5 ng/ml [sensitivity, 80%; 95% confidence interval (CI), 67-89%; and specificity, 60%; 95% CI, 45-78%]. The study concluded that the detection of recurrence by 18F-FDG PET/CT in patients treated for CRC is associated with CEA, but not CA 19-9 serum levels. Moreover, 18F-FDG PET/CT should be recommended in patients with suspected CRC recurrence even when they present with CEA levels below the normal cut-off. |
| Databáze: | OpenAIRE |
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