Pathogenesis of Brucella ovis in pregnant mice and protection induced by the candidate vaccine strain B. Ovis ΔabcBA

Autor:	Heloísia Maria Bressan, Braz, Monique Ferreira, Silva, Thaynara Parente de, Carvalho, Laice Alves da, Silva, Jefferson Bruno, Soares, Fabíola Barroso, Costa, Brunno Gardiman, Sossai, Tatiane Alves da, Paixão, Renato Lima, Santos
Rok vydání:	2022
Předmět:	Mice Inbred BALB C Vaccines Sheep General Veterinary General Immunology and Microbiology Brucella ovis Public Health Environmental and Occupational Health Brucella Vaccine Brucella abortus Brucellosis Mice Infectious Diseases Pregnancy Animals Molecular Medicine Female Spleen
Zdroj:	Vaccine. 40:4617-4624
ISSN:	0264-410X
Popis:	Ovine brucellosis caused by Brucella ovis is a major cause of reproductive failure in sheep. This study aimed to evaluate transplacental infection and pathogenicity of B.ovis wild type strain ATCC 25,840 (WT B.ovis) and the candidate vaccine strain B.ovis ΔabcBA in pregnant mice. A total of 40 BALB/c mice were equally divided into 4 groups: (i) non immunized and uninfected control mice (3/10 mice became pregnant); (ii) non immunized and challenged with WT B.ovis (5/10 pregnant); (iii) inoculated only with B.ovis ΔabcBA (6/10 pregnant); (iv) immunized with B.ovis ΔabcBA and challenged with WT B.ovis (5/10 pregnant). Female mice bred, and five days after visualization of the vaginal plug, they were inoculated intraperitoneally (ip) with 100 µL of sterile PBS, 100 µL of 1 × 10
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e2855b181946f69cf87a1ea612fbd6 https://doi.org/10.1016/j.vaccine.2022.06.044 Zobrazit plný text záznamu Full Text from ScienceDirect