Modulation of the renin-aldosterone system by iodotyrosines as tyrosine hydroxylase inhibitors
| Autor: | Stanley A. Tan, Linda G. Tan, Lee Berk |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Monoiodotyrosine medicine.medical_specialty Tyrosine 3-Monooxygenase Dopamine Endocrinology Diabetes and Metabolism Hypokalemia Stimulation Biochemistry Renin-Angiotensin System chemistry.chemical_compound Internal medicine Hyperaldosteronism Renin–angiotensin system medicine Humans Tyrosine Hydroxylase Inhibitor Tyrosine Aldosterone Tyrosine hydroxylase medicine.disease Endocrinology chemistry Diiodotyrosine medicine.drug |
| Zdroj: | Biochemical Medicine and Metabolic Biology. 44:252-258 |
| ISSN: | 0885-4505 |
| DOI: | 10.1016/0885-4505(90)90069-d |
| Popis: | This study shows that MIT and DIT stimulate aldosterone secretion. This may be due to their tyrosine hydroxylase inhibitory property. Dopamine abolishes the stimulation. Prolonged MIT administration enhances the stimulation of aldosterone secretion and can cause hypokalemia. Volume expansion reverses the hyperaldosteronism. PRA and blood pressure do not change, even after prolonged MIT intake. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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