Screening for distant metastases in patients with head and neck cancer
| Autor: | Jonas A. Castelijns, Jolijn Brouwer, Asaf Senft, Remco de Bree, Richard P. Golding, C. René Leemans, Emile F.I. Comans, Otto S. Hoekstra |
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| Přispěvatelé: | Otolaryngology / Head & Neck Surgery, Radiology and nuclear medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Thorax
Adult Male Cancer Research medicine.medical_specialty Malignancy Sensitivity and Specificity Metastasis Fluorodeoxyglucose F18 medicine Humans Prospective Studies Lung cancer Aged Aged 80 and over business.industry Head and neck cancer Neoplasms Second Primary Middle Aged medicine.disease Oncology Epidermoid carcinoma Head and Neck Neoplasms Hepatocellular carcinoma Positron-Emission Tomography Carcinoma Squamous Cell Adenocarcinoma Female Radiology Oral Surgery Radiopharmaceuticals business |
| Zdroj: | Oral Oncology, 42(3), 275-280. Elsevier Limited Brouwer, J, Senft, A, De Bree, R, Comans, E F I, Golding, R P, Castelijns, J A, Hoekstra, O S & Leemans, C R 2006, ' Screening for distant metastases in patients with head and neck cancer : Is there a role for 18 FDG-PET? ', Oral Oncology, vol. 42, no. 3, pp. 275-280 . https://doi.org/10.1016/j.oraloncology.2005.07.009 |
| ISSN: | 1368-8375 |
| Popis: | The detection of distant metastases and second primary tumours at the time of initial evaluation changes the prognosis and influences the selection of treatment modality in patients with HNSCC. Until recently chest CT was the single most effective test to screen for distant metastases in HNSCC patients. In this observational cohort study we prospectively compared the yield of whole body 18FDG-PET and chest CT to detect distant metastases and synchronous primary tumours. The results of whole body 18FDG-PET and chest CT were analysed in 34 consecutive HNSCC patients with previously established risk factors for the presence of distant metastases. Four patients were diagnosed with distant metastases or second primary tumours: CT as well as 18FDG-PET identified one patient with lung metastases and another with primary lung cancer. In addition, 18FDG-PET detected second primary tumours in two patients (hepatocellular carcinoma and abdominal adenocarcinoma). However increased uptake sites at 18FDG-PET in lung, liver and pelvis in five patients were not confirmed by other imaging modalities. The added value of whole body 18FDG-PET versus chest CT was to identify unknown malignancy in 6% of the patients. Confirmation of positive 18FDG-PET findings is feasible and necessary. |
| Databáze: | OpenAIRE |
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