Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2
| Autor: | Alex Sparreboom, William D. Figg, Erin R. Lepper, Milin Acharya, Jaap Verweij, Kees Nooter |
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| Přispěvatelé: | Medical Oncology |
| Rok vydání: | 2005 |
| Předmět: |
ATP Binding Cassette Transporter
Subfamily B Abcg2 Organic Anion Transporters ATP-binding cassette transporter Antineoplastic Agents Drug resistance Genetics medicine ATP Binding Cassette Transporter Subfamily G Member 2 Humans ATP Binding Cassette Transporter Subfamily B Member 1 Gene P-glycoprotein Pharmacology Polymorphism Genetic biology Cancer Biological Transport medicine.disease Neoplasm Proteins Drug Resistance Neoplasm Area Under Curve biology.protein Molecular Medicine ATP-Binding Cassette Transporters Pharmacogenetics Function (biology) |
| Zdroj: | Pharmacogenomics, 6(2), 115-138. Future Medicine Ltd. |
| ISSN: | 1462-2416 |
| Popis: | ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein) and ABCG2 (breast cancer-resistance protein [BCRP], mitoxantrone-resistance protein [MXR], or ABC transporter in placenta [ABCP]), are also known to influence oral absorption and disposition of a wide variety of drugs. As a result, the expression levels of these proteins in humans have important consequences for an individual’s susceptibility to certain drug-induced side effects, interactions, and treatment efficacy. Naturally occurring variants in ABC transporter genes have been identified that might affect the function and expression of the protein. This review focuses on recent advances in the pharmacogenetics of the ABC transporters ABCB1 and ABCG2, and discusses potential implications of genetic variants for the chemotherapeutic treatment of cancer. |
| Databáze: | OpenAIRE |
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