Dexmedetomidine May Reduce IL-6 Level and the Risk of Postoperative Cognitive Dysfunction in Patients After Surgery: A Meta-Analysis
Autor: | Yeqin Sha, Songhui Xie, Li Liu, Daoyun Lei, Chao Han, Shuang Wen |
---|---|
Rok vydání: | 2020 |
Předmět: |
endocrine system
Health Toxicology and Mutagenesis MEDLINE Review Toxicology 03 medical and health sciences 0302 clinical medicine Clinical work cognition disorders postoperative Medicine In patient 030212 general & internal medicine Dexmedetomidine Interleukin 6 Chemical Health and Safety biology business.industry lcsh:RM1-950 Public Health Environmental and Occupational Health dexmedetomidine medicine.disease lcsh:Therapeutics. Pharmacology inflammation Meta-analysis Anesthesia biology.protein business Postoperative cognitive dysfunction 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Dose-Response, Vol 18 (2020) Dose-Response |
ISSN: | 1559-3258 |
Popis: | Dexmedetomidine (DEX) was widely used in clinical work. However, the effectiveness of DEX on postoperative cognitive dysfunction (POCD) was still need to be confirmed. The aim of this meta-analysis was to explore whether DEX can reduce the incidence of POCD on the first day and seventh postoperative day. The results showed that lower incidence of POCD associated with DEX treatment on the first (odds ratio [OR]: 0.41; 95% confidence interval [CI]: 0.31-0.54) or seventh postoperative day (OR: 0.53; 95% CI: 0.36-0.77). Mini-Mental State Examination scores on the first (mean difference [MD]: 4.67; 95% CI: 1.72-7.63) and seventh postoperative days (MD: 3.71; 95% CI: 2.51-4.90) were higher in DEX use group than that in physiological saline group. Meanwhile, neuron-specific enolase (NSE; MD: −3.99; 95% CI: −6.20 to −1.78) and interleukin 6 (IL-6) levels (MD: −17.53; 95% CI: −21.51 to −13.54) on the first postoperative day in DEX group were lower than that in the physiological saline group. This meta-analysis suggested that DEX use could reduce the risk of POCD and the reduction in levels of NSE and IL-6 can improve long-term cognitive dysfunction and anti-inflammation. |
Databáze: | OpenAIRE |
Externí odkaz: |