Bioactivity-Guided Isolation of Anti-Inflammatory Principles from Cistus parviflorus Lam
| Autor: | Miyase Gözde Gündüz, Şengül Dilem Doğan, Gizem Celik, Hatice Bekci, Ahmet Cumaoğlu, Mehmet Yavuz Paksoy, Perihan Gürbüz |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Traditional medicine Isolation (health care) medicine.drug_class Organic Chemistry food and beverages Plant Science Biology Cistus parviflorus Anti-inflammatory lcsh:QK1-989 lcsh:Chemistry lcsh:QD241-441 cistaceae inflammation flavonoids structure elucidation avicularin molecular modelling lcsh:QD1-999 lcsh:Organic chemistry lcsh:Botany Drug Discovery medicine |
| Zdroj: | Records of Natural Products, Vol 13, Iss 3, Pp 226-235 (2019) |
| Popis: | Bioactivity-guided fractionation and purification of Cistus parvillorus led to the isolation of two flavan-3-ol derivatives; gallocatechin (1) and epigallocatechin (2) and two flavonoid glycosides; avicularin (3) and trans-tiliroside (4). The structures of the compounds were elucidated on the basis of NMR and ESIMS data. All compounds were isolated from C. parviflorus for the first time. Compounds 2 and 3 exhibited antiinflammatory activity through decreasing the NOS2 and COX2 levels on LPS+IFN-gamma treated RAW 264.7 cells. Molecular docking studies of avicularin, the most potent compound, were carried out in the active sites of NOS2 and COX2 to predict the most plausible binding modes and support the experimental data. |
| Databáze: | OpenAIRE |
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