Doubtful association of antipsychotic polypharmacy and high dosage with cognition in chronic schizophrenia
| Autor: | Stamatina Kalogerakou, Angeliki Andreopoulou, Charalambos Karouzos, Yannis Makris, Dimitrios Kontis, Spyridon Kleisas, Eirini Theochari, Eleftheria Tsaltas, Rafael Psaras |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty medicine.drug_class medicine.medical_treatment Neuropsychological Tests Anticholinergic medicine Humans Effects of sleep deprivation on cognitive performance Antipsychotic Adverse effect Psychiatry Biological Psychiatry Retrospective Studies Psychiatric Status Rating Scales Pharmacology Polypharmacy Dose-Response Relationship Drug medicine.diagnostic_test Neuropsychological test Middle Aged medicine.disease Schizophrenia Chronic Disease Female Schizophrenic Psychology Cognition Disorders Psychology Antipsychotic Agents |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 34:1333-1341 |
| ISSN: | 0278-5846 |
| Popis: | Despite consistent recommendations for antipsychotic monotherapy, antipsychotic polypharmacy (the use of two or more antipsychotic agents) and the administration of excessive doses (higher than 1000 mgr/day of chloropromazine equivalents) is a common practice in schizophrenia. The therapeutic and adverse effects of this practice are poorly studied, in particular with regards to the cognitive symptoms of the disease. In this cross-sectional study we investigated the cognitive effects of antipsychotic polypharmacy and excessive doses in 53 patients with chronic schizophrenia using non-verbal cognitive tasks involving speed of movement, memory and executive functions. No significant difference in performance scores was found between the groups under polypharmacy and monotherapy, or the groups receiving either excessive or normal doses of antipsychotics. Since these groups did not also differ in demographic, clinical, other pharmacologic parameters, in the relative anticholinergic potency of antipsychotics, or in intelligence scores, we raise doubts about the association of polypharmacy and excessive doses with non-verbal cognitive performance in chronic schizophrenia. |
| Databáze: | OpenAIRE |
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