Evaluation of bacteriochlorophyll-reconstituted low-density lipoprotein nanoparticles for photodynamic therapy efficacy in vivo
| Autor: | E. Paul Wileyto, Britton Chance, Ian R. Corbin, Jerry D. Glickson, Hui Li, Diane Marotta, Gang Zheng, Theresa M. Busch, Elizabeth Rickter, Weiguo Cao |
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| Rok vydání: | 2011 |
| Předmět: |
Hepatoblastoma
Pathology medicine.medical_specialty Materials science medicine.medical_treatment Biomedical Engineering Medicine (miscellaneous) Mice Nude Bioengineering Photodynamic therapy Development Article chemistry.chemical_compound Mice Drug Delivery Systems In vivo Cell Line Tumor Neoplasms medicine Animals Humans General Materials Science Photosensitizer Receptor Photosensitizing Agents Cancer medicine.disease Xenograft Model Antitumor Assays chemistry Photochemotherapy Low-density lipoprotein Cancer research Nanoparticles Lipoprotein |
| Zdroj: | Nanomedicine (London, England). 6(3) |
| ISSN: | 1748-6963 |
| Popis: | Aim: To evaluate the novel nanoparticle reconstituted bacteriochlorin e6 bisoleate low-density lipoprotein (r-Bchl-BOA-LDL) for its efficacy as a photodynamic therapy agent delivery system in xenografts of human hepatoblastoma G2 (HepG2) tumors. Materials & methods: Bchl-BOA was encapsulated in the nanoparticle low-density lipoprotein (LDL), a native particle whose receptor’s overexpression is a cancer signature for a number of neoplasms. Evaluation of r-Bchl-BOA-LDL as a potential photosensitizer was performed using a tumor response and foot response assay. Results & discussion: When compared with controls, tumor regrowth was significantly delayed at injected murine doses of 2 µmole/kg r-Bchl-BOA-LDL after illumination at fluences of 125, 150 or 175 J/cm2. Foot response assays showed that although normal tissue toxicity accompanied the higher fluences it was significantly reduced at the lowest fluence tested. Conclusion: This research demonstrates that r-Bchl-BOA-LDL is an effective photosensitizer and a promising candidate for further investigation. |
| Databáze: | OpenAIRE |
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