How helminths use excretory secretory fractions to modulate dendritic cells

Autor:	Katerina Artavanis-Tsakonas, Rhiannon R. White
Rok vydání:	2012
Předmět:	Microbiology (medical) Virulence Factors dendritic cell Immunology Helminthiasis Review Immunoglobulin E Microbiology 03 medical and health sciences Th2 0302 clinical medicine Helminths TLR parasitic diseases medicine Eosinophilia Animals Humans Immunologic Factors Antigen-presenting cell helminth Th1 immunity 030304 developmental biology 0303 health sciences biology Dendritic cell Dendritic Cells Excretory secretory medicine.disease 3. Good health Infectious Diseases ES Host-Pathogen Interactions parasite biology.protein Parasitology medicine.symptom 030215 immunology
Zdroj:	Virulence
ISSN:	2150-5608
Popis:	It is well known that helminth parasites have immunomodulatory effects on their hosts. They characteristically cause a skew toward T(H)2 immunity, stimulate Treg cells while simultaneously inhibiting T(H)1 and T(H)17 responses. Additionally, they induce eosinophilia and extensive IgE release. The exact mechanism of how the worms achieve this effect have yet to be fully elucidated; however, parasite-derived secretions and their interaction with antigen presenting cells have been centrally implicated. Herein, we will review the effects of helminth excretory-secretory fractions on dendritic cells and discuss how this interaction is crucial in shaping the host response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d86fa0fa963943de617308e75b61e1 https://pubmed.ncbi.nlm.nih.gov/23221477 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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