Genetic variation at the porcine MYF-5 gene locus. Lack of association with meat production traits

Autor: M.F.W. te Pas, F.L. Harders, L. Born, A. Soumillion, W. Buist, Theodorus Meuwissen
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Male
Meat
Genotype
Swine
Molecular Sequence Data
Muscle Proteins
Locus (genetics)
Biology
Sequence Homology
Nucleic Acid
Genetic variation
Genetics
Life Science
Gene family
Animals
Birth Weight
Allele
Cloning
Molecular
Deoxyribonucleases
Type II Site-Specific
Gene
Instituut voor Dierhouderij en Diergezondheid
Myogenin
Polymorphism
Genetic
ID-Lelystad
Base Sequence
Body Weight
Genetic Variation
DNA
Sequence Analysis
DNA
ID Lelystad
DNA-Binding Proteins
Genes
ID-Lelystad
Instituut voor Dierhouderij en Diergezondheid
Data Interpretation
Statistical
ID Lelystad
Institute for Animal Science and Health
Trans-Activators
Microsatellite
Female
Myogenic Regulatory Factor 5
Restriction fragment length polymorphism
Institute for Animal Science and Health
Polymorphism
Restriction Fragment Length
Microsatellite Repeats
Zdroj: Mammalian Genome, 10, 123-127
Mammalian Genome 10 (1999)
ISSN: 0938-8990
Popis: The number of muscle fibers at birth appears to determine the maximal lean meat growth capacity in pigs and in cattle. Development of muscle fibers is regulated by the MyoD gene family consisting of MyoD1, myf-5, myf-6, and myogenin. Myf-5 is expressed in proliferating myoblasts. Here we report the genomic sequence of the porcine myf-5 gene with three microsatellites and two RFLPs located close to the coding sequences. Two of the microsatellites are located in the promoter region. The allelic distribution differs between breeds and selection lines. In two GY selection lines, 1216 pigs of two-generation families were genotyped for the HinfI RFLP, which was segregating in the GY breed. The other polymorphic loci are physically linked to this RFLP locus, and therefore the results can be extrapolated to these loci. Statistical analysis revealed no association with birth weight, growth rate, weight at slaughter age, carcass meat weight, and backfat thickness. Thus, in this study myf-5 did not explain genetic variation in meat (muscle) development in pigs.
Databáze: OpenAIRE
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