Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion
| Autor: | Duncan J. Maitland, John Horn, Ward Small, Anthony J. Boyle, Landon D. Nash, Jennifer N. Rodriguez, Cheng-Kang Yang, Hunter Skoog, Thomas S. Wilson, Jason M. Ortega, Matthew W. Miller |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
Polymers Swine Biomedical Engineering Biocompatible Materials Permeability Article Biomaterials Materials Testing Alloys Animals Composite material Elastic modulus Mechanical Phenomena chemistry.chemical_classification Hemostasis Cell Membrane Cell migration Shape-memory alloy Polymer Isotropic etching Shape-memory polymer Membrane chemistry Mechanics of Materials Permeability (electromagnetism) Blood Vessels |
| Zdroj: | Journal of the Mechanical Behavior of Biomedical Materials. 40:102-114 |
| ISSN: | 1751-6161 |
| Popis: | Predominantly closed-cell low density shape memory polymer (SMP) foam was recently reported to be an effective aneurysm filling device in a porcine model (Rodriguez et al., Journal of Biomedical Materials Research Part A 2013: (http://dx.doi.org/10.1002/jbm.a.34782)). Because healing involves blood clotting and cell migration throughout the foam volume, a more open-cell structure may further enhance the healing response. This research sought to develop a non-destructive reticulation process for this SMP foam to disrupt the membranes between pore cells. Non-destructive mechanical reticulation was achieved using a gravity-driven floating nitinol pin array coupled with vibratory agitation of the foam and supplemental chemical etching. Reticulation resulted in a reduced elastic modulus and increased permeability, but did not impede the shape memory behavior. Reticulated foams were capable of achieving rapid vascular occlusion in an in vivo porcine model. |
| Databáze: | OpenAIRE |
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