Chicory Roots for Prebiotics and Appetite Regulation: A Pilot Study in Mice
| Autor: | Rozenn Ravallec, Georges Daube, Marion Fouré, Benoit Cudennec, Abigael Delcourt, Camille Dugardin, Philippe Hance, Thierry Cadalen, Jean-Louis Hilbert, Anca Lucau-Danila, Bernard Taminiau, Benoît Foligné |
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| Přispěvatelé: | Institut Charles Viollette (ICV) - EA 7394 (ICV), Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de la Recherche Agronomique (INRA)-Université d'Artois (UA)-Institut Supérieur d'Agriculture, Centre Hospitalier Universitaire de Lille (CHU de Lille), Université de Liège, University of Lille, European Union, French Region of Hauts-de-France, Université d'Artois (UA)-Institut National de la Recherche Agronomique (INRA)-Université du Littoral Côte d'Opale (ULCO)-Institut Supérieur d'Agriculture-Université de Lille |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Firmicutes [SDV]Life Sciences [q-bio] medicine.medical_treatment metagenetics Enteroendocrine cell Gut flora Chicory Mice 03 medical and health sciences satiety hormones Metabolomics Cichorium medicine [SDV.BV]Life Sciences [q-bio]/Vegetal Biology Animals Food science Alistipes 2. Zero hunger 030109 nutrition & dietetics Bacteria biology Appetite Regulation Plant Extracts Prebiotic Bacteroidetes General Chemistry biology.organism_classification metabolomics Gastrointestinal Microbiome Gastrointestinal Tract Prebiotics 030104 developmental biology Digestion General Agricultural and Biological Sciences Cichorium intybus |
| Zdroj: | Journal of Agricultural and Food Chemistry Journal of Agricultural and Food Chemistry, American Chemical Society, 2018, 66 (25), pp.6439-6449. ⟨10.1021/acs.jafc.8b01055⟩ Journal of Agricultural and Food Chemistry, 2018, 66 (25), pp.6439-6449. ⟨10.1021/acs.jafc.8b01055⟩ |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | International audience; The objectives of this work are to address the prebiotic effects of chicory (Cichorium intybus) together with its possible role in appetite control. We compared nine chicory genotypes in order to determine if variations in the content of metabolites in the roasted roots would lead to modifications in release of satiety hormones and in composition of gut microbiota. To this aim, a 5-week dietary-intervention study was achieved using mice fed with distinct chicory-based preparations. A 16S rRNA gene-based metagenetic analysis of fecal microbiota was performed. In vitro gastrointestinal digestions were performed in order to study the effect of chicory intestinal digests on gut hormone regulation in enteroendocrine cells. Firmicutes/ Bacteroidetes ratio and gut bacterial groups, such as Alloprevotella, Blautia, Alistipes, and Oscillibacter, were found to be modulated by chicory. On the other hand, CCK and GLP-1 satiety hormones were demonstrated to be significantly increased by chicory in vitro. |
| Databáze: | OpenAIRE |
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