Influence of lung transplantation on the essential fatty acid profile in cystic fibrosis
| Autor: | Sid Ali Namane, Anne Malfroot, Georges Casimir, Jean Duchateau, Christiane Knoop, Laurence Hanssens |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Cystic Fibrosis medicine.medical_treatment Clinical Biochemistry 030209 endocrinology & metabolism Gastroenterology Cystic fibrosis 03 medical and health sciences Plasma Young Adult 0302 clinical medicine Essential fatty acid Internal medicine Lung status Medicine Lung transplantation Humans Prospective Studies Child chemistry.chemical_classification Médecine clinique [chimie clinique] 030109 nutrition & dietetics Lung Fatty Acids Essential business.industry Erythrocyte Membrane Homozygote Cell Biology medicine.disease Erythrocyte membrane medicine.anatomical_structure chemistry Docosahexaenoic acid Biologie cellulaire Polyunsaturated fatty acids Female business Polyunsaturated fatty acid Lung Transplantation |
| Zdroj: | Prostaglandins, leukotrienes and essential fatty acids |
| ISSN: | 1532-2823 |
| Popis: | Lung transplantation is assumed to normalize essential fatty acid (EFA) profile in the plasma, described as abnormal in patients with cystic fibrosis (CF). This study sought to evaluate the EFA profile in both the plasma and erythrocyte membrane according to lung status by comparing CF patients with or without a lung transplant. A total of 50 homozygous F508del patients (33 CF patients [CF group] and 17 CF patients with a lung transplant [TX CF group]) were included. In comparison with the CF group, in the plasma, the levels of total n-3, α-linolenic, eicosapentaenoic, and docosahexaenoic acids were higher and the n-6/n-3 ratio was lower in the TX CF group. Yet, these differences were not observed in the erythrocyte membrane. This study supports that lung transplantation improves the EFA profile in the plasma but not in the erythrocyte membrane by means of the different mechanisms suggested in this article. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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