Do schizophrenics well adapted in the community need neuroleptics?: A DEPOT NEUROLEPTIC WITHDRAWAL STUDY
| Autor: | S. J. Dencker, M. Lepp, Ulf Malm |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pediatrics
medicine.medical_specialty Time Factors Depot medicine.medical_treatment Flupenthixol Recurrence Rating scale Ambulatory Care medicine Humans Antipsychotic Psychiatry Psychiatric Status Rating Scales Control period Clopenthixol Substance Withdrawal Syndrome Psychiatry and Mental health Patient population Delayed-Action Preparations Chronic Disease Cohort Schizophrenia Psychology Social Adjustment Antipsychotic Agents Follow-Up Studies |
| Zdroj: | Acta Psychiatrica Scandinavica. 61:64-76 |
| ISSN: | 0001-690X |
| Popis: | Two depot neuroleptics (flupenthixol palmitate and clopemthixol de canoate) used for at least 15 months were withdrawn in 32 schizephrenic outpatients belonging to the most symptom-free and social cohort of a total patient population. They all had only slight schizophrenic symptoms, were well adapted in the community, and had been free from relapse for at least 2 years before the study. They were assessed by means of rating scales every month during the first six months and then after 9 and 12 months. After the one-year trial 26 patients had relapsed. Moreover, after the control period further 4 out of 6 patients relapsed during the following drug-free year. These results indicate the necessity of a long follow-up period after withdrawal of depot neuroleptics. Moreover, the results suggest that periodical drug-free periods of about 3 months are appropriate in symptom-poor patients during long-term treatment with long-acting antipsychotic drugs. |
| Databáze: | OpenAIRE |
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