Increased Cardiovascular Stiffness and Impaired Age-related Functional Status
| Autor: | Sandra Soots, Sujethra Vasu, Stephen B. Kritchevsky, Dalane W. Kitzman, Timothy M. Morgan, Don Hire, William G Hundley, Mousumi M. Andersen, Craig A. Hamilton, Tina E. Brinkley |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Aging medicine.medical_specialty Activities of daily living Brachial Artery Pulse Wave Analysis Physical function Disability Evaluation Vascular Stiffness Risk Factors Surveys and Questionnaires Internal medicine Age related Activities of Daily Living medicine Humans Mobility Limitation Aged Heart Failure Body surface area business.industry Stroke volume Middle Aged medicine.disease Magnetic Resonance Imaging Pulse pressure Heart failure Cardiology Physical therapy Original Article Female Functional status Geriatrics and Gerontology business |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 70:545-553 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glu085 |
| Popis: | Our objective was to determine if increased cardiovascular (CV) stiffness is associated with disability in middle-aged and older adults at risk for congestive heart failure. CV stiffness (brachial pulse pressure/left ventricular stroke volume indexed to body surface area) and total disability (the summed assessment of activities of daily living, mobility, and instrumental activities of daily living) were measured in 445 individuals. A subset of 109 randomly selected individuals also underwent physical function testing. Total disability was associated with CV stiffness (p = .01), driven by an association with mobility (p = .005), but not activities of daily living (p = .13) or instrumental activities of daily living (p = .61). After accounting for age, these correlations remained significant for men (p = .04), but not for women. CV stiffness was also associated with increased 400-m walk time (p = .02). In middle-aged and elderly men at risk for congestive heart failure, CV stiffness is associated with decreased mobility and physical function, and increased overall disability. |
| Databáze: | OpenAIRE |
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