Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus
| Autor: | Miha Tibaut, Franjo Naji, Daniel Petrovič |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
type 2 diabetes mellitus
Cyclin Dependent Kinase Inhibitor 2B Antisense RNA 1 CDKN2B-AS1 Slovenia Myocardial Infarction Polymorphism Single Nucleotide miokardni infarkt myocardial infarction bolezen koronarnih arterij Cross-Sectional Studies rs1333049 coronary artery disease Diabetes Mellitus Type 2 Case-Control Studies Genetics Humans sladkorna bolezen tip 2 Genetic Predisposition to Disease RNA Antisense RNA Long Noncoding Genetics (clinical) udc:616.1 Retrospective Studies |
| Zdroj: | Genes, vol. 13, no. 3, 526, 2022. Genes; Volume 13; Issue 3; Pages: 526 |
| ISSN: | 2073-4425 |
| Popis: | Background: We examined the role of rs1333049 polymorphism of the CDKN2B Antisense RNA 1 (CDKN2B-AS1) on the prevalence of myocardial infarction (MI) in Slovenian subjects with type 2 diabetes mellitus (T2DM). Methods: A total of 1071 subjects with T2DM were enrolled in this retrospective cross-sectional case-control study. Of the subjects, 334 had a history of recent MI, and 737 subjects in the control group had no clinical signs of coronary artery disease (CAD). With logistic regression, we performed a genetic analysis of rs1333049 polymorphism in all subjects. Results: The C allele of rs1333049 polymorphism was statistically more frequent in MI subjects (p = 0.05). Subjects with CC genotype had a higher prevalence of MI than the control group in the co-dominant (AOR 1.50, CI 1.02–2.21, p = 0.04) and recessive (AOR 1.38, CI 1.09–1.89, p = 0.04) genetic model. Conclusions: According to our study, the C allele and CC genotype of rs1333049 polymorphism of CDKN2B-AS1 are possible markers of MI in T2DM subjects in the Slovenian population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|