Influence of a chronic administration of diethylnitrosamine on the relation between specific tissular and division functions in the rat liver
| Autor: | H. Barbason, Jacques Van Cantfort |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty Nitrosamines Cell division medicine.medical_treatment Mitosis Biology medicine.disease_cause Cholesterol 7 alpha-hydroxylase Internal medicine Hepatic carcinogenesis medicine Animals Hepatectomy Diethylnitrosamine Circadian rhythm Cholesterol 7-alpha-Hydroxylase Liver Neoplasms Neoplasms Experimental General Medicine Circadian Rhythm Rats Endocrinology Liver Rat liver Steroid Hydroxylases Microsomes Liver Carcinogenesis Cell Division |
| Zdroj: | European Journal of Cancer (1965). 11:531-536 |
| ISSN: | 0014-2964 |
| DOI: | 10.1016/0014-2964(75)90124-3 |
| Popis: | The evolution of the division and specific tissular functions, in the liver, which are mutually exclusive of young and partially hepatectomised adult rats, was studied during hepatic carcinogenesis induced by the chronic administration of diethylnitrosamine. The results show that one of the phenomena implicated in this chemical carcinogenesis is the deregulation of the normal equilibrium between the specific tissular and the division functions. In effect, during the preneoplasic stages, these two functions are progressively disrupted; they lose their normal exclusive relationship and their specific nychtermeral rhythms. These abnormalities are observed in the unoperated as well as partially hepatectomised rats. |
| Databáze: | OpenAIRE |
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