Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis in Canada
| Autor: | Jonathan A. Micieli, Edward Margolin, Anubhav Garg |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Canada medicine.medical_specialty Optic Neuritis Visual acuity Adolescent genetic structures medicine.medical_treatment Nerve fiber layer Myelin oligodendrocyte glycoprotein Young Adult chemistry.chemical_compound Ophthalmology medicine Humans Optic neuritis Aged Autoantibodies Retrospective Studies medicine.diagnostic_test biology business.industry Optic Nerve Magnetic resonance imaging Immunosuppression Retinal General Medicine Middle Aged medicine.disease eye diseases medicine.anatomical_structure Neurology chemistry biology.protein Optic nerve Female Myelin-Oligodendrocyte Glycoprotein Neurology (clinical) medicine.symptom business |
| Zdroj: | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 48:321-326 |
| ISSN: | 2057-0155 0317-1671 |
| Popis: | Objective:To describe clinical characteristics of Canadian patients with myelin-oligodendrocyte glycoprotein immunoglobulin-G optic neuritis (MOG-IgG ON).Methods:Retrospective observational case series of MOG-IgG seropositive patients with ON referred to tertiary neuro-ophthalmology practices. Outcome measures included clinical characteristics, radiologic findings, and visual outcomes.Results:Forty-six eyes of 30 patients were included. Twenty-three (76.7%) were women, mean onset age was 40.7 years (range 16–77), and most were Caucasian. Seventeen (56.7%) presented with their first ON episode. Sixteen (53.3%) had bilateral eye involvement. Isolated ON without associated neurological symptoms occurred in 90.0%. In 22 patients with acute ON (seen within 1 month of onset), presenting mean visual acuity (VA) was 20/258 (logMAR 1.11), mean deviation (MD) on Humphrey visual fields was −16.90 ± 10.83 dB, and peripapillary retinal nerve fiber layer (RNFL) thickness on ocular coherence tomography (OCT) was 164.23 ± 46.53 um. Orbital magnetic resonance imaging (MRI) within 1 month of symptom onset for 19 patients demonstrated orbital optic nerve enhancement in 11 (57.9%) and perineural enhancement in 11 (57.9%). Brain MRI was normal in 28 (93.3%) patients. Twenty out of 22 patients with acute presentation were treated with high-dose glucocorticoids and 5 with plasma exchange in addition to corticosteroids. Long-term immunosuppression was utilized in 9 (30%) out of all 30 patients. Final VA was 20/30 (logMAR 0.18), MD was −7.17 ± 8.85 dB, and RNFL thickness was 72.15 ± 20.16 um.Conclusion:MOG-IgG ON in Canada has a variable presentation with most patients having substantial initial vision loss with good recovery. This is the largest characterization of the disease in Canada to date. |
| Databáze: | OpenAIRE |
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