Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system
| Autor: | Peter J. Bryant, Daniel F. Woods, Kenneth D. Konrad, Kellie L. Watson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Ribosomal Proteins
Mitotic crossover Tumor suppressor gene Cellular differentiation Mutant Molecular Sequence Data Restriction Mapping Genes Insect Biology Ribosomal protein Animals Humans Genes Tumor Suppressor Amino Acid Sequence Gene Ribosomal Protein S6 Multidisciplinary Base Sequence Genetic Complementation Test Chromosome Mapping biology.organism_classification Molecular biology Hematopoiesis Drosophila melanogaster Ribosomal protein s6 Sequence Alignment Cell Division Research Article |
| Popis: | The tumor suppressor gene lethal(1)aberrant immune response 8 (air8) of Drosophila melanogaster encodes a homolog of the human S6 ribosomal protein. P element insertions that prevent expression of this gene cause overgrowth of the lymph glands (the hematopoietic organs), abnormal blood cell differentiation, and melanotic tumor formation. They also cause delayed development, inhibit growth of most of the larval organs, and lead to larval lethality. Mitotic recombination experiments indicate that the normal S6 gene is required for clone survival in the germ line and imaginal discs. The S6 gene produces a 1.1-kilobase transcript that is abundant throughout development in wild-type animals and in revertants derived from the insertional mutants but is barely detectable in the mutant larvae. cDNAs corresponding to this transcript show a 248-amino acid open reading frame with 75.4% identity and 94.8% similarity to both human and rat S6 ribosomal protein sequences. The results reveal a regulatory function of this ribosomal protein in the hematopoietic system of Drosophila that may be related to its developmentally regulated phosphorylation. |
| Databáze: | OpenAIRE |
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