Legg-Calve-Perthes disease in two generations of male family members: a case report
| Autor: | Mir Sadat-Ali, Ammar K Al-Omran |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Avascular necrosis Disease Femoral head lcsh:Orthopedic surgery medicine Legg-Calve-Perthes disease Humans Genetic Predisposition to Disease Child Collagen Type II business.industry medicine.disease Surgery Radiography lcsh:RD701-811 Family member medicine.anatomical_structure Femur head necrosis Legg-Calve-Perthes Disease Col2a1 gene business Early osteoarthritis |
| Zdroj: | Journal of Orthopaedic Surgery, Vol 21 (2013) |
| ISSN: | 2309-4990 |
| Popis: | Legg-Calve-Perthes disease (LCPD) is a type of avascular necrosis of the femoral head occurring mainly in male children and causing early osteoarthritis. We report 2 generations of 4 male family members with LCPD-like features and mutation of the COL2A1 gene of the 12q13 chromosome. If LCPD occurs in any family member, we recommend genetic analysis and counselling as well as early radiological screening of related children. |
| Databáze: | OpenAIRE |
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