Diabetes Mellitus—A Risk Factor for Unfavourable Outcome in COVID-19 Patients—The Experience of an Infectious Diseases Regional Hospital
| Autor: | Cristian Prepeliuc, Daniela Leca, Claudia Elena Pleşca, Oana Stamateanu, Larisa Miftode, Tudorița Gabriela Părângă, Maria Obreja, Ioana Coman, Egidia Miftode |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Leadership and Management Population Health Informatics Disease Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tocilizumab Health Information Management Diabetes mellitus Internal medicine Medicine 030212 general & internal medicine Risk factor education 030304 developmental biology 0303 health sciences education.field_of_study biology business.industry Health Policy COVID-19 medicine.disease chemistry Monoclonal cytokine storm diabetes mellitus biology.protein Antibody business Cytokine storm |
| Zdroj: | Healthcare, Vol 9, Iss 788, p 788 (2021) Healthcare Volume 9 Issue 7 |
| ISSN: | 2227-9032 |
| Popis: | Early research into the implications concerning the evolution of the infection caused by the new coronavirus in people with glucose metabolism dysfunction, in this case diabetics, shows that severe forms of the disease predominate in this risk category. Moreover, it seems that even in patients with normal glycaemic status, COVID-19 may predispose to the development of hyperglycaemia which modulates immune mechanisms and inflammatory responses, with direct effects on morbidity and mortality. Thus, taking into account these scientific data, as well as the increased frequency of diabetes in the general population, we aimed to assess the risk of an unfavourable outcome of diabetic patients, which is in a strong connection with the presence and severity of pulmonary disease such as interstitial pneumonia/bronchopneumonia, as well as the effectiveness of Tocilizumab administration. The results of our study indicate a three-fold higher risk of death in patients with diabetes and COVID-19 (RR = 3.03 IC95%: 2.37–3.86 p = 0.001),compared to nondiabetic patients, and the risk of developing severe forms of acute respiratory failure was 1.5 times higher in the first studied category. In conclusion, we can say that the diabetic diagnosed with SARS-CoV-2 infection is more predisposed to immunological and organic dysfunctions that may ultimately result in death, and treatment with monoclonal anti-IL-6 antibodies was more effective in diabetic patients than non-diabetics (p < 0.05). The effectiveness of Tocilizumab was significant in both studied groups, but diabetic patients responded better to this therapy compared to non-diabetes-mellitus (DM) ones (76.7% vs. 35% p = 0.001). |
| Databáze: | OpenAIRE |
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