Solid-phase synthesis of cyclic PNA and PNA-DNA chimeras
| Autor: | Daniela Montesarchio, De Napoli L, Anna Messere, Di Fabio G, Moggio L, Di Blasio B, Jennifer D'Onofrio |
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| Přispěvatelé: | Moggio, L., DE NAPOLI, L., DI BLASIO, B., DI FABIO, G., D'Onofrio, J., Montesarchio, D., Messere, Anna, L., Moggio, DE NAPOLI, Lorenzo, B., DI BLASIO, DI FABIO, Giovanni, J., Donofrio, Montesarchio, Daniela, A., Messere |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
chemistry.chemical_classification
Peptide Nucleic Acids modified oligonucleotide Molecular Structure Chemistry Stereochemistry solid-phase synthesi circular dumbbell oligonucleotides solid phase synthesi Organic Chemistry Peptide DNA DNA-PNA chimera Biochemistry Combinatorial chemistry PNA-DNA chimeras chemistry.chemical_compound Solid-phase synthesis Cyclization Molecule cyclic PNA Physical and Theoretical Chemistry Linker cyclic molecule |
| Popis: | A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide and phosphoramidite-based chemistry has been achieved. © 2006 American Chemical Society. |
| Databáze: | OpenAIRE |
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