Accelerated ketoprofen release from spray-dried polymeric particles: importance of phase transitions and excipient distribution
| Autor: | Emilie Gue, Elisabeth Delcourt-Debruyne, Jean-François willart, Juergen Siepmann, Florence Danede, S. Muschert, Marc Descamps |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Ketoprofen
Polymers Chemistry Pharmaceutical Pharmaceutical Science Excipient Phase Transition Excipients chemistry.chemical_compound Hypromellose Derivatives X-Ray Diffraction Drug Discovery medicine Particle Size Dissolution Pharmacology chemistry.chemical_classification Supersaturation Ethanol Chromatography Calorimetry Differential Scanning Organic Chemistry Temperature Povidone Polymer Drug Liberation chemistry Chemical engineering Solubility Spray drying Particle-size distribution Microscopy Electron Scanning Crystallization medicine.drug |
| Zdroj: | Drug development and industrial pharmacy. 41(5) |
| ISSN: | 1520-5762 |
| Popis: | HPMC-, PVPVA- and PVP-based microparticles loaded with 30% ketoprofen were prepared by spray drying suspensions or solutions in various water:ethanol blends. The inlet temperature, drying gas and feed flow rates were varied. The resulting differences in the ketoprofen release rates in 0.1 M HCl could be explained based on X-ray diffraction, mDSC, SEM and particle size analysis. Importantly, long term stable drug release could be provided, being much faster than: (i) drug release from a commercial reference product, (ii) the respective physical drug:polymer mixtures, as well as (iii) the dissolution of ketoprofen powder as received. In addition, highly supersaturated release media were obtained, which did not show any sign for re-crystallization during the observation period. Surprisingly, spraying suspensions resulted in larger microparticles exhibiting faster drug release compared to spraying solutions, which resulted in smaller particles exhibiting slower drug release. These effects could be explained based on the physico-chemical characteristics of the systems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|