Formation of diaryl sulfides and sulfoxides: Synthesis, characterization and structure activity correlation studies

Autor:	D. S. Lamani, Srikant G. Badiger, Mamata Singh
Rok vydání:	2019
Předmět:	Inorganic Chemistry Structure activity correlation 010405 organic chemistry Computational chemistry Chemistry Organic Chemistry Carbon-13 NMR 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Characterization (materials science)
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 194:789-795
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426507.2018.1547720
Popis:	The synthesis of a series of stable diarylsulfides and sulfoxides is reported. All the newly synthesized compounds were characterized by 1H, 13C NMR and mass spectroscopic techniques. A detailed mechanistic study indicates that the formation of sulfoxides follows the oxidation. In addition to synthesis, characterization and mechanistic studies, the glutathione peroxidase(GPx) mimetic activity of the newly synthesized compounds is described. It is observed that the diaryl sulfides having a heterocyclic ring attached to the nitrogen atom facilitates the oxidation of the sulfur center to form the corresponding sulfoxides. The substituents attached to the nitrogen atom play an important role in the catalytic activity of the substituted diaryl sulfides. The obtained data supports for the higher antioxidant activity of diaryl sulfides than that of the corresponding sulfoxides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cba71228036ab8dd0abdc00fead218 https://doi.org/10.1080/10426507.2018.1547720 Zobrazit plný text záznamu