Consistent Decrease in Telomere Length in Parathyroid Tumors but Alteration in Telomerase Activity Limited to Malignancies: Preliminary Report
| Autor: | Hajime Kanauchi, Kaiyo Takubo, Yoshikazu Mimura, Makoto Kammori, Michio Kaminishi, Masaki Kawahara, Takao Obara, Kenichi Nakamura |
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| Rok vydání: | 2002 |
| Předmět: |
Adenoma
Adult Male Telomerase Pathology medicine.medical_specialty Restriction fragment Parathyroid Glands Biomarkers Tumor Humans Medicine Aged chemistry.chemical_classification Hyperplasia biology business.industry Nucleic acid amplification technique Middle Aged Telomere medicine.disease Parathyroid Neoplasms Enzyme chemistry Parathyroid carcinoma biology.protein Cancer research Female Surgery business Nucleic Acid Amplification Techniques hormones hormone substitutes and hormone antagonists |
| Zdroj: | World Journal of Surgery. 26:1083-1087 |
| ISSN: | 1432-2323 0364-2313 |
| DOI: | 10.1007/s00268-002-6409-2 |
| Popis: | Telomerase is known to be activated and telomere length altered in various types of malignant and benign tumors, but whether this is also the case for parathyroid lesions has hitherto been unclear. We therefore investigated telomerase activity and telomere length in 3 parathyroid metastatic cancers, 6 adenomas, 2 cases of parathyroid hyperplasia, and 16 samples of normal parathyroid tissue. Telomerase activity, assayed by the telomeric repeat amplification protocol, was detected in all of the parathyroid cancers (100%), in none of the 8 parathyroid benign lesions, and in only 1 of the 16 normal parathyroid samples (8.3%). Telomere length, determined by the terminal restriction fragment assay, was reduced in the tumor tissues with a mean telomere length of 8.23 +/- 0.86 kbp compared with the 12.61 +/- 0.81 kbp for the 16 age-matched subjects (p = 0.002). The results indicate that telomerase activity and telomere length may reflect the biologic behavior of individual parathyroid lesions. |
| Databáze: | OpenAIRE |
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