Influence of alpha-tocopherol on the inhibition of beta-glucuronidase by peroxidized linoleic acid
| Autor: | L. H. Chen, Leonard V. Packett |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Linoleic acid Medicine (miscellaneous) Ascorbic Acid Anisoles In Vitro Techniques Antioxidants chemistry.chemical_compound Internal medicine medicine Animals Vitamin E Butylated hydroxytoluene Vitamin E Deficiency heterocyclic compounds Cysteine Glucuronidase chemistry.chemical_classification Nutrition and Dietetics biology Air food and beverages Glutathione Ascorbic acid Enzyme assay Peroxides Rats Enzyme Endocrinology Linoleic Acids Liver chemistry Biochemistry Depression Chemical Barbiturates biology.protein lipids (amino acids peptides and proteins) alpha-Tocopherol Oxidation-Reduction Toluene |
| Zdroj: | The American Journal of Clinical Nutrition. 24:1232-1237 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/24.10.1232 |
| Popis: | in activities of some enzymes, occurs in tocopherol deficiency. High levels of dietary unsaturated fatty acids hasten the onset of deficiency symptoms. Experimental muscular dystrophy in rabbits and chicks, induced by tocopherol deficiency, results in increased activity of the lysosomal enzyme, f3-glucuronidase, in the muscle and liver (2, 3). Tappel (4) suggested that thisincreasewas due to increased fragilityof the lysosomes. However, the opposite effect has been observed in the liver and other organs of rats (5). These species differences in /3-glucuronidase activity of tocopherol-deficient animals have not been explained. This study attempts to determine: a) the effect of peroxidized linoleic acid on the total /3-glucuronidase activity of normal rat liver preparation, and the influence of added a-tocopherol; b) the effect of a-tocopherol on the /3-glucuronidase activity in the liver of normal and tocopherol-deficient rats; and c) the effect of peroxidized linoleic acid in the presence of a-tocopherol, both added in vitro, on the /3-glucuronidase activity of liver preparationof normal and tocopherol-deficient rats. |
| Databáze: | OpenAIRE |
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