Evaluation of Hypoglycemic and Antioxidative Effects of Synthesized Peptide MC62

Autor:	Meng Ru, Wenlong Huang, Baowei Yang, Hai Qian, Xuekun Wang, Sijia Yan, Xin Deng, Wei Chen, Hong Chen, Jing Jin, Guolong Gu, Yicheng Mei
Rok vydání:	2013
Předmět:	Blood Glucose Male medicine.medical_specialty endocrine system diseases Molecular Sequence Data Positive control Peptide medicine.disease_cause Biochemistry Streptozocin Diabetes Mellitus Experimental Islets of Langerhans Mice Malondialdehyde Internal medicine Diabetes mellitus Drug Discovery medicine Animals Hypoglycemic Agents Amino Acid Sequence Glycated Hemoglobin Pharmacology chemistry.chemical_classification Glutathione Peroxidase geography geography.geographical_feature_category Superoxide Dismutase business.industry Body Weight Organic Chemistry Diabetic mouse Islet Streptozotocin medicine.disease Glutathione Oxidative Stress Endocrinology chemistry Molecular Medicine Peptides business Exenatide Oxidative stress medicine.drug
Zdroj:	Chemical Biology & Drug Design. 82:99-105
ISSN:	1747-0277
Popis:	Diabetes mellitus has been considered as a major health problem in the world today. This study aimed to investigate the hypoglycemic and antioxidative effects of peptide MC62 which was synthesized by solid-phase peptide synthesis method against diabetes induced by streptozotocin. MC62 was administered daily and injected intraperitoneally to the diabetic mice at a dose of 1 μmol/kg body weight for 20 days. The levels of fasting blood glucose and HbA1C, pancreatic islet damage, and associated changes in antioxidative activities were evaluated in streptozotocin-induced diabetic mice used the exenatide as positive control. After the administration of MC62 together with exenatide for 20 days, the elevated fasting blood glucose and HbA1C levels were reduced, and antioxidative activities were restored. It was confirmed with the histological finding that MC62 prevented the islet from damage in diabetic mice. This indicated that MC62 can prevent mice from hyperglycemia which may be associated with oxidative stress. It also suggested that MC62 could be used as a safe alternative hypoglycemic candidate for treatment of diabetes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c95e3106bfec5446a313e0f9005257 https://doi.org/10.1111/cbdd.12137 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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