Correlation between the level of cytogenetic aberrations in cultured human lymphocytes and the age and gender of donors
| Autor: | Alina Wojda, Krzysztof Skrzypczak, Włodzimierz Pawłowski, Małgorzata Mossakowska, Michał Witt, Ewa Ziętkiewicz |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Aging Mitotic index Cell Culture Techniques Physiology Average level Biology Correlation Age and gender Sex Factors Mitotic Index Humans Lymphocytes X chromosome Cellular Senescence Aged Genetics Aged 80 and over Chromosome Aberrations Case-control study Age Factors Karyotype Middle Aged Cytogenetic Aberrations Case-Control Studies Karyotyping Female Poland Geriatrics and Gerontology |
| Zdroj: | The journals of gerontology. Series A, Biological sciences and medical sciences. 61(8) |
| ISSN: | 1079-5006 |
| Popis: | To answer whether the age-related accumulation of chromosomal damage differs in men and women, and whether the aberration level in centenarians is proportional to their age, cytogenetic aberrations in dividing cells were analyzed. G-band karyotyping of mitotic spreads from lymphocytes was performed in 52 Polish centenarians and 71 controls (aged 21-78). Statistical evaluation was performed using nonparametric tests and regression analysis. The average level of all chromosomal aberrations was comparable in centenarians of both genders, but the age-related increase in chromosomal damage occurred faster in women than in men. Aging in both genders was marked by the increasing level of all aberrations rather than by chromosome-specific changes; the loss of X chromosome was the leading contributor in women. The age-related increase in the level of chromosomal damage reflected accumulation of dividing cells with a small number of aberrations. Individuals who survive to the extreme old age appear to accumulate aberrations at the slower rate. |
| Databáze: | OpenAIRE |
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