Protective effects of dichloroacetic acid on endometrial injury and ovarian reserve in an experimental rat model of diabetes mellitus
| Autor: | Burcu Artunc Ulkumen, Halil Gursoy Pala, Emel Ebru Pala, Oytun Erbaş |
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| Rok vydání: | 2021 |
| Předmět: |
Anti-Mullerian Hormone
medicine.medical_specialty Endometrial Cycle medicine.medical_treatment Dichloroacetic acid Endometrium Diabetes Mellitus Experimental chemistry.chemical_compound Fibrosis Internal medicine Diabetes mellitus Follicular phase medicine Animals Ovarian Reserve Ovarian reserve Hysterectomy Dichloroacetic Acid business.industry Obstetrics and Gynecology medicine.disease Rats medicine.anatomical_structure Endocrinology chemistry Female business |
| Zdroj: | Journal of Obstetrics and Gynaecology Research. 47:4319-4328 |
| ISSN: | 1447-0756 1341-8076 |
| DOI: | 10.1111/jog.15045 |
| Popis: | AIM To study (1) ovarian and endometrial damage caused by the hyperglycemia and (2) the effects of dichloroacetic acid (DCA) on follicular reserve and endometrial damage in streptozocin induced diabetic rats. METHODS This study consisted 24 rats randomly separated into three groups. A diabetes model was achieved in 16 rats experimentally, and normoglycemic eight rats were assigned as control group (Group 1). The rats with diabetes were randomly separated to two groups: 1 mL/kg/day intraperitoneal 0.9% NaCl was given to eight rats as diabetic vehicle (Group 2) and 10 mg/kg/day DCA was given to other eight rats as DCA treated group (Group 3). Hysterectomy with bilateral oophorectomy was performed for histopathological evaluation and blood samples were collected after 4 weeks. RESULTS Diabetes caused ovarian and endometrial damage (p |
| Databáze: | OpenAIRE |
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