Evaluation of the Disintegration Time of Rapidly Disintegrating Tablets via a Novel Method Utilizing a CCD Camera
| Autor: | Masanobu Yasui, Junko Ajioka, Kozo Takayama, Yuki Tsushima, Yutaka Morita, Ryoji Termoz |
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| Rok vydání: | 2002 |
| Předmět: |
Diagnostic Imaging
Chemical Phenomena Ccd camera Drug Compounding Excipients parasitic diseases Drug Discovery Area under curve Pharmaceutic Aids Mannitol Computer vision Particle Size Cellulose Drug compounding Chemistry Physical Chemistry business.industry Povidone General Chemistry General Medicine Kinetics Japanese Pharmacopoeia Solubility Area Under Curve Polyvinyl Alcohol Personal computer Artificial intelligence business Tablets |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 50:1181-1186 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.50.1181 |
| Popis: | Many kinds of rapidly disintegrating or oral disintegrating tablets (RDT) have been developed to improve the ease of tablet administration, especially for elderly and pediatric patients. In these cases, knowledge regarding disintegration behavior appears important with respect to the development of such a novel tablet. Ordinary disintegration testing, such as the Japanese Pharmacopoeia (JP) method, faces limitations with respect to the evaluation of rapid disintegration due to strong agitation. Therefore, we have developed a novel apparatus and method to determine the dissolution of the RDT. The novel device consists of a disintegrating bath and CCD camera interfaced with a personal computer equipped with motion capture and image analysis software. A newly developed RDT containing various types of binder was evaluated with this protocol. In this method, disintegration occurs in a mildly agitated medium, which allows differentiation of minor distinctions among RDTs of different formulations. Simultaneously, we were also able to detect qualitative information, i.e., morphological changes in the tablet during disintegration. This method is useful for the evaluation of the disintegration of RDT during pharmaceutical development, and also for quality control during production. |
| Databáze: | OpenAIRE |
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