Increased CD1d polymorphism: identification of two novel alleles, CD1d*03 and *04, in individuals from Morocco
| Autor: | A. Aureli, T. Del Beato, Daniela Piancatelli, M. Di Rocco, R. El Aouad, Alessandra Tessitore, Khadija Oumhani |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Protein Conformation
Immunology Molecular Sequence Data Nucleotide substitution chemical and pharmacologic phenomena Biology Exon Polymorphism (computer science) parasitic diseases Genetics Humans Nucleotide Allele Molecular Biology Genetics (clinical) Alleles chemistry.chemical_classification Polymorphism Genetic Transition (genetics) CD1 hemic and immune systems General Medicine Exons Sequence Analysis DNA Molecular biology carbohydrates (lipids) Morocco chemistry Amino Acid Substitution G-domain CD1D biology.protein lipids (amino acids peptides and proteins) Antigens CD1d |
| Zdroj: | International journal of immunogenetics (Online) 42 (2015): 287–291. doi:10.1111/iji.12210 info:cnr-pdr/source/autori:Aureli A.; Oumhani K.; Del Beato T.; Di Rocco M.;Tessitore A.; El Aouad R.; Piancatelli D./titolo:Increased CD1d polymorphism: identification of two novel alleles, CD1d*03 and *04, in individuals from Morocco./doi:10.1111%2Fiji.12210/rivista:International journal of immunogenetics (Online)/anno:2015/pagina_da:287/pagina_a:291/intervallo_pagine:287–291/volume:42 |
| DOI: | 10.1111/iji.12210 |
| Popis: | Summary Two novel CD1D alleles were identified in unrelated individuals from Morocco. They differ each from the common CD1D*01 allele by one nucleotide substitution in exon 2 resulting in one amino acid change in the G-ALPHA1-LIKE domain. According to the IMGT unique numbering for G domain, CD1D*03 has one nucleotide transition c136 > t in codon 46, with an arginine-to-cysteine amino acid change (R46 > C) in the D-STRAND, whereas CD1D*04 has one transition c98 > t in codon 33, with a threonine-to-methionine amino acid change (T33 > M) in the C-STRAND. This suggests that CD1D is more polymorphic than previously assumed. |
| Databáze: | OpenAIRE |
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