Tripartite motif-containing proteins precisely and positively affect host antiviral immune response
| Autor: | Shun Le Chen, Anchun Cheng, M. S. Wang, Yunan Wei |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
animal structures viruses Ubiquitin-Protein Ligases Immunology Biology Virus Replication Virus Tripartite Motif Proteins 03 medical and health sciences Immune system Viral life cycle Protein Domains medicine Humans Innate immune system 030102 biochemistry & molecular biology Ubiquitination General Medicine Virology Immunity Innate 030104 developmental biology Viral replication Virus Diseases Interferon Type I Signal transduction Interferon type I medicine.drug Signal Transduction |
| Zdroj: | Scandinavian journal of immunology. 87(6) |
| ISSN: | 1365-3083 |
| Popis: | The tripartite motif-containing proteins (TRIMs) comprise a large family of proteins with over 70 members in humans. Recent studies have shown that TRIMs play unexpected roles in the antiviral immune responses to infections by HIV, MLV, EMCV, AIV and other viruses. There are two mechanisms used by TRIMs in the inhibition of virus infections: (1) TRIMs target the produced viruses for ubiquitination, which induces proteasome-dependent degradation, or they interact with host proteins to inhibit viral infection in various periods of the viral life cycle. (2) TRIMs activate innate immune signalling pathways, such as RLR and TLR, which induce IFN production. In this study, we will review recent studies regarding the means by which TRIMs function as inhibitors in viral infection through the mechanisms described above. |
| Databáze: | OpenAIRE |
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