The NIR inspired nano-CuSMn(II) composites for lactate and glycolysis attenuation
| Autor: | Xiu-Lin Fang, Robertson Akrofi, Qiu-Yun Chen, Huan Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Infrared Rays
Surface Properties Lactate dehydrogenase A 02 engineering and technology 01 natural sciences Nanocomposites chemistry.chemical_compound Folic Acid Colloid and Surface Chemistry 0103 physical sciences Animals Glycolysis Lactic Acid Particle Size Physical and Theoretical Chemistry Pyruvates Bifunctional education education.field_of_study Interventional treatment 010304 chemical physics Serum Albumin Bovine Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology In vitro Lactic acid Manganese Compounds chemistry Hypoxia-inducible factors Biochemistry Cattle Pyruvic acid 0210 nano-technology Oxidation-Reduction Copper Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 181:728-733 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2019.06.031 |
| Popis: | The level of lactate and hypoxia inducible factor (HIF) in cells has effect on tumor growth and drug resistance. The glycolysis of tumors could be inhibited by reducing the expression of lactate dehydrogenase A (LDHA) or the mutual conversion of lactic acid and pyruvic acid. To develop a bifunctional nanoparticle as both the cleaner of lactate and attenuator of glycolysis, a NIR (near infrared) responsive nanoparticle (Mn-CuS@BSA-FA) was synthesized and characterized. The Mn-CuS@BSA-FA catalyzed the oxidation of lactate to pyruvate under NIR irradiation. In vitro assay results demonstrate that Mn-CuS@BSA-FA can decrease the activity of LDHA and attenuate the conversion of lactate to pyruvate. Moreover, Mn-CuS@BSA-FA can inhibit the expression of HIF-1 and decrease the ATP level in HepG-1 cells. Our work demonstrates that Mn-CuS@BSA-FA can be a NIR enhanced glycolytic inhibitor for cancer interventional treatment. |
| Databáze: | OpenAIRE |
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