The site of binding of anti-CEA antibodies to tumour CEA in vivo: an immunocytochemical and autoradiographic approach
| Autor: | A M Neville, S F Imrie, J H Westwood, V Moshakis, M G Ormerod |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Cancer Research
Antibodies Neoplasm Transplantation Heterologous Immunocytochemistry Breast Neoplasms Cell membrane Mice Carcinoembryonic antigen In vivo Carcinoma medicine Extracellular Animals Humans biology Neoplasms Experimental medicine.disease Molecular biology Carcinoembryonic Antigen medicine.anatomical_structure Oncology Cytoplasm Mice Inbred CBA biology.protein Autoradiography Female Binding Sites Antibody Antibody Neoplasm Transplantation Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1982.159 |
| Popis: | Radiolabelled affinity-purified antibody to carcinoembryonic antigen (CEA) was injected i.v. into immune-suppressed mice carrying xenografts of human breast carcinoma. Its distribution in the tumours was examined by a combination of immunocytochemistry and autoradiography. The antibody interacted predominantly with the CEA in the extracellular tumour space, rather than on the cell membrane or cytoplasm. Images Figure |
| Databáze: | OpenAIRE |
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